Publications

Max Planck Unit For The Science of Pathogens

Publications

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Journal Article (60)

2024

Huerta M, Cornejo F, Aburto C, Illanes A, Vera C and Guerrero C. (2024). Enzymatic production of rare sugars with a new mutant of cellobiose 2-epimerase from Caldicellulosiruptor saccharolyticus. Bioresource Technology, 391, 129936.

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Lautenschläger N, Schmidt K, Schiffer C, Wulff TF, Hahnke K, Finstermeier K, Mansour M, Elsholz AKW and Charpentier E. (2024). Expanding the genetic toolbox for the obligate human pathogen Streptococcus pyogenes. Frontiers in Bioengineering and Biotechnology, 12.

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Muñoz-Gutierrez V, Cornejo FA, Schmidt K, Frese CK, Halte M, Erhardt M, Elsholz AKW, Turgay K and Charpentier E. (2024). Bacillus subtilis remains translationally active after CRISPRi-mediated replication initiation arrest. mSystems, 9.

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2023

Goldlust K, Ducret A, Halte M, Dedieu-Berne A, Erhardt M and Lesterlin C. (2023). The F pilus serves as a conduit for the DNA during conjugation between physically distant bacteria. Proc. Natl. Acad. Sci. U.S.A., 120(47), e2310842120.

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Naseri G, Raasch H, Charpentier E and Erhardt M. (2023). A versatile regulatory toolkit of arabinose-inducible artificial transcription factors for Enterobacteriaceae. Communications biology, 6(1), 1005.

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Broglia L, Le Rhun A and Charpentier E. (2023). Methodologies for bacterial ribonuclease characterization using RNA-seq. FEMS microbiology reviews, 47(5).

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Grätz L, Kowalski-Jahn M, Scharf MM, Kozielewicz P, Jahn M, Bous J, Lambert NA, Gloriam DE and Schulte G. (2023). Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations. Nat Commun, 14(1), 4573.

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Hu H, Popp PF, Santiveri M, Roa-Eguiara A, Yan Y, Martin FJO, Liu Z, Wadhwa N, Wang Y, Erhardt M and Taylor NMI. (2023). Ion selectivity and rotor coupling of the Vibrio flagellar sodium-driven stator unit. Nature communications, 14(1), 4411.

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Miao R, Jahn M, Shabestary K, Peltier G and Hudson EP. (2023). CRISPR interference screens reveal growth–robustness tradeoffs in Synechocystis sp. PCC 6803 across growth conditions. The Plant Cell, koad208.

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Saleh DO, Horstmann JA, Giralt-Zúñiga M, Weber W, Kaganovitch E, Durairaj AC, Klotzsch E, Strowig T and Erhardt M. (2023). SPI-1 virulence gene expression modulates motility of Salmonella Typhimurium in a proton motive force- and adhesins-dependent manner. PLoS pathogens, 19(6), e1011451.

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Naseri G. (2023). A roadmap to establish a comprehensive platform for sustainable manufacturing of natural products in yeast. Nat Commun, 14(1), 1916.

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Driller K, Cornejo FA and Turgay K. (2023). (p)ppGpp – an important player during heat shock response. microLife, 4, uqad017.

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Hengge R, Pruteanu M, Stülke J, Tschowri N and Turgay K. (2023). Recent advances and perspectives in nucleotide second messenger signaling in bacteria. microLife, 4, uqad015.

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Roske Y, Lindemann F, Diehl A, Cremer N, Higman VA, Schlegel B, Leidert M, Driller K, Turgay K, Schmieder P, Heinemann U and Oschkinat H. (2023). TapA acts as specific chaperone in TasA filament formation by strand complementation. Proceedings of the National Academy of Sciences, 120.

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Wulff TF, Hahnke K, Lécrivain A-L, Schmidt K, Ahmed-Begrich R, Finstermeier K and Charpentier E. (2023). Dynamics of diversified A-to-I editing in Streptococcus pyogenes is governed by changes in mRNA stability. bioRxiv.

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2022

Christensen S, Rämisch S and André I. (2022). DnaK response to expression of protein mutants is dependent on translation rate and stability. Communications Biology, 5(1), 597.

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Tcyganov EN, Sanseviero E, Marvel D, Beer T, Tang H-Y, Hembach P, Speicher DW, Zhang Q, Donthireddy LR, Mostafa A, Tsyganova S, Pisarev V, Laufer T, Ignatov D, Ferrone S, Meyer C, Maby-El Hajjami H, Speiser DE, Altiok S, … Gabrilovich DI. (2022). Peroxynitrite in the tumor microenvironment changes the profile of antigens allowing escape from cancer immunotherapy. Cancer Cell, 40(10), 1173–1189.e6.

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Buttress JA, Halte M, te Winkel JD, Erhardt M, Popp PF and Strahl H. (2022). A guide for membrane potential measurements in Gram-negative bacteria using voltage-sensitive dyes. Microbiology, 168(9), 001227 .

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Popp PF and Erhardt M. (2022). Supercoiled filaments propel them all. Cell, 185(19), 3461–3463.

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Stelbrink B, Von Rintelen T, Richter K, Finstermeier K, Frahnert S, Cracraft J and Hofreiter M. (2022). Insights into the geographical origin and phylogeographical patterns of Paradisaea birds-of-paradise. Zoological Journal of the Linnean Society, zlac010.

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Halte M, Wörmann ME, Bogisch M, Erhardt M and Tschowri N. (2022). BldD‐based bimolecular fluorescence complementation for in vivo detection of the second messenger cyclic di‐GMP. Molecular Microbiology, 117(3), 705–713.

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Badr A, Eltobgy M, Krause K, Hamilton K, Estfanous S, Daily KP, Abu Khweek A, Hegazi A, Anne MNK, Carafice C, Robledo-Avila F, Saqr Y, Zhang X, Bonfield TL, Gavrilin MA, Partida-Sanchez S, Seveau S, Cormet-Boyaka E, Amer AO et al. (2022). CFTR Modulators Restore Acidification of Autophago-Lysosomes and Bacterial Clearance in Cystic Fibrosis Macrophages. Frontiers in Cellular and Infection Microbiology, 12.

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2021

Glaser LV, Steiger M, Fuchs A, van Bömmel A, Einfeldt E, Chung H-R, Vingron M and Meijsing SH. (2021). Assessing genome-wide dynamic changes in enhancer activity during early mESC differentiation by FAIRE-STARR-seq. Nucleic Acids Research (London), 49(21), 12178–12195.

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Vowinckel J, Hartl J, Marx H, Kerick M, Runggatscher K, Keller MA, Mülleder M, Day J, Weber M, Rinnerthaler M, Yu JSL, Aulakh SK, Lehmann A, Mattanovich D, Timmermann B, Zhang N, Dunn CD, MacRae JI, Breitenbach M et al. (2021). The metabolic growth limitations of petite cells lacking the mitochondrial genome. Nature Metabolism, 3(11), 1521–1535.

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Bothe M, Buschow R and Meijsing SH. (2021). Glucocorticoid signaling induces transcriptional memory and universally reversible chromatin changes. Life science alliance, 4(10).

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Guse A, Halte M, Hüsing S and Erhardt M. (2021). Hook‐basal‐body assembly state dictates substrate specificity of the flagellar type‐III secretion system. Molecular Microbiology, 116(4), 1189–1200.

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Birk MS, Charpentier E and Frese CK. (2021). Automated Phosphopeptide Enrichment for Gram-Positive Bacteria. Journal of Proteome Research, 20(10), 4886–4892.

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Birk MS, Ahmed-Begrich R, Tran S, Elsholz AKW, Frese CK and Charpentier E. (2021). Time-Resolved Proteome Analysis of Listeria monocytogenes during Infection Reveals the Role of the AAA+ Chaperone ClpC for Host Cell Adaptation. mSystems, 6(4), e00215–21.

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Estfanous S, Daily KP, Eltobgy M, Deems NP, Anne MNK, Krause K, Badr A, Hamilton K, Carafice C, Hegazi A, Abu Khweek A, Kelani H, Nimjee S, Awad H, Zhang X, Cormet-Boyaka E, Haffez H, Soror S, Mikhail A, … Amer AO. (2021). Elevated Expression of MiR-17 in Microglia of Alzheimer’s Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation. Frontiers in immunology, 12, 705581.

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Krishnamoorthy G, Kaiser P, Constant P, Frese CK, Abu Abed U, Schmid M, Brinkmann V, Daffé M and Kaufmann SHE. (2021). Role of Premycofactocin Synthase in Growth, Microaerophilic Adaptation, and Metabolism of Mycobacterium tuberculosis. mBio, 12(4), e0166521.

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Hüsing S, Halte M, van Look U, Guse A, Gálvez EJC, Charpentier E, Blair DF, Erhardt M and Renault TT. (2021). Control of membrane barrier during bacterial type-III protein secretion. Nature Communications, 12(1), 3999.

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Beerens D, Franch-Arroyo S, Sullivan TJ, Goosmann C, Brinkmann V and Charpentier E. (2021). Survival Strategies of Streptococcus pyogenes in Response to Phage Infection. Viruses, 13(4), 612.

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Kulik M, Bothe M, Kibar G, Fuchs A, Schöne S, Prekovic S, Mayayo-Peralta I, Chung H-R, Zwart W, Helsen C, Claessens F and Meijsing SH. (2021). Androgen and glucocorticoid receptor direct distinct transcriptional programs by receptor-specific and shared DNA binding sites. Nucleic Acids Research (London), 49(7), 3856–3875.

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Apel F, Andreeva L, Knackstedt LS, Streeck R, Frese CK, Goosmann C, Hopfner K-P and Zychlinsky A. (2021). The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps. Science Signaling, 14(673), eaax7942.

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Estfanous S, Krause K, Anne MNK, Eltobgy M, Caution K, Abu Khweek A, Hamilton K, Badr A, Daily K, Carafice C, Baetzhold D, Zhang X, Li T, Wen H, Gavrilin MA, Haffez H, Soror S and Amer AO. (2021). Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo. Scientific Reports, 11(1), 855.

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Estfanous S, Krause K, Anne MNK, Eltobgy M, Caution K, Khweek AA, Hamilton K, Badr A, Daily K, Carafice C, Baetzhold D, Zhang X, Li T, Wen H, Gavrilin MA, Haffez H, Soror S and Amer AO. (2021). Author Correction: Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo. Scientific Reports, 11(1), 12447.

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Oliveira T, Zhang M, Joo EJ, Abdel-Azim H, Chen C-W, Yang L, Chou C-H, Qin X, Chen J, Alagesan K, Almeida A, Jacob F, Packer NH, von Itzstein M, Heisterkamp N and Kolarich D. (2021). Glycoproteome remodeling in MLL-rearranged B-cell precursor acute lymphoblastic leukemia. Theranostics, 11(19), 9519–9537.

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Otaru N, Ye K, Mujezinovic D, Berchtold L, Constancias F, Cornejo FA, Krzystek A, de Wouters T, Braegger C, Lacroix C and Pugin B. (2021). GABA Production by Human Intestinal Bacteroides spp.: Prevalence, Regulation, and Role in Acid Stress Tolerance. Frontiers in Microbiology, 12, 656895.

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2020

Bae-Gartz I, Kasper P, Großmann N, Breuer S, Janoschek R, Kretschmer T, Appel S, Schmitz L, Vohlen C, Quaas A, Schweiger MR, Grimm C, Fischer A, Ferrari N, Graf C, Frese CK, Lang S, Demir M, Schramm C, … Hucklenbruch-Rother E. (2020). Maternal exercise conveys protection against NAFLD in the offspring via hepatic metabolic programming. Scientific Reports, 10(1), 15424.

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Gálvez EJC, Iljazovic A, Amend L, Lesker TR, Renault T, Thiemann S, Hao L, Roy U, Gronow A, Charpentier E and Strowig T. (2020). Distinct Polysaccharide Utilization Determines Interspecies Competition between Intestinal Prevotella spp. Cell Host & Microbe, 28(6), 838–852.e6.

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Lichtenegger S, Stiehler J, Saiger S, Zauner A, Kleinhappl B, Bernecker C, Schlenke P, Wagner GE, Krause K, Gastager M and Steinmetz I. (2020). Burkholderia pseudomallei triggers canonical inflammasome activation in a human primary macrophage-based infection model. PLoS Neglected Tropical Diseases, 14(11), e0008840.

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Schnirch L, Nadler-Holly M, Siao S-W, Frese CK, Viner R and Liu F. (2020). Expanding the Depth and Sensitivity of Cross-Link Identification by Differential Ion Mobility Using High-Field Asymmetric Waveform Ion Mobility Spectrometry. Analytical Chemistry, 92(15), 10495–10503.

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Bratovič M, Fonfara I, Chylinski K, Gálvez EJC, Sullivan TJ, Boerno S, Timmermann B, Boettcher M and Charpentier E. (2020). Bridge helix arginines play a critical role in Cas9 sensitivity to mismatches. Nature Chemical Biology, 16(5), 587–595.

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Righetti F, Materne SL, Boss J, Eichner H, Charpentier E and Loh E. (2020). Characterization of a transcriptional TPP riboswitch in the human pathogen Neisseria meningitidis. RNA Biology, 17(5), 718–730.

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Schäfer H, Beckert B, Frese CK, Steinchen W, Nuss AM, Beckstette M, Hantke I, Driller K, Sudzinová P, Krásný L, Kaever V, Dersch P, Bange G, Wilson DN and Turgay K. (2020). The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis. PLoS Genetics, 16(3), e1008275.

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Broglia L, Lécrivain A-L, Renault TT, Hahnke K, Ahmed-Begrich R, Le Rhun A and Charpentier E. (2020). An RNA-seq based comparative approach reveals the transcriptome-wide interplay between 3'-to-5' exoRNases and RNase Y. Nature Communications, 11(1), 1587.

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Lautenschläger N, Popp PF and Mascher T. (2020). Development of a novel heterologous β-lactam-specific whole-cell biosensor in Bacillus subtilis. Journal of Biological Engineering, 14, 21.

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Makarova KS, Wolf YI, Iranzo J, Shmakov SA, Alkhnbashi OS, Brouns SJJ, Charpentier E, Cheng D, Haft DH, Horvath P, Moineau S, Mojica FJM, Scott D, Shah SA, Siksnys V, Terns MP, Venclovas Č, White MF, Yakunin AF, … Koonin EV. (2020). Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants. Nature Reviews Microbiology, 18, 67–83.

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Pausch P, Abdelshahid M, Steinchen W, Schäfer H, Gratani FL, Freibert S-A, Wolz C, Turgay K, Wilson DN and Bange G. (2020). Structural Basis for Regulation of the Opposing (p)ppGpp Synthetase and Hydrolase within the Stringent Response Orchestrator Rel. Cell Reports, 32(11), 108157.

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2019

Zhan X, Li B, Zhan X, Schlüter H, Jungblut PR and Coorssen JR. (2019). Innovating the Concept and Practice of Two-Dimensional Gel Electrophoresis in the Analysis of Proteomes at the Proteoform Level. Proteomes, 7(4), 36.

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Ratner HK, Escalera-Maurer A, Le Rhun A, Jaggavarapu S, Wozniak JE, Crispell EK, Charpentier E and Weiss DS. (2019). Catalytically Active Cas9 Mediates Transcriptional Interference to Facilitate Bacterial Virulence. Molecular Cell, 75(3), 498–510.e5.

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Le Rhun A, Escalera-Maurer A, Bratovič M and Charpentier E. (2019). CRISPR-Cas in Streptococcus pyogenes. RNA Biology, 16(4), 380–389.

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Ugolini M and Sander LE. (2019). Dead or alive: how the immune system detects microbial viability. Current Opinion in Immunology, 56, 60–66.

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Mulvenna N, Hantke I, Burchell L, Nicod S, Bell D, Turgay K and Wigneshweraraj S. (2019). Xenogeneic modulation of the ClpCP protease of Bacillus subtilis by a phage-encoded adaptor-like protein. The Journal of Biological Chemistry, 294(46), 17501–17511.

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2018

Lécrivain A-L, Le Rhun A, Renault TT, Ahmed-Begrich R, Hahnke K and Charpentier E. (2018). In vivo 3'-to-5' exoribonuclease targetomes of Streptococcus pyogenes. Proceedings of the National Academy of Sciences of the United States of America, 115(46), 11814–11819.

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Tsatsaronis JA, Franch-Arroyo S, Resch U and Charpentier E. (2018). Extracellular Vesicle RNA: A Universal Mediator of Microbial Communication? Trends in Microbiology, 26(5), 401–410.

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Hille F, Richter H, Wong SP, Bratovič M, Ressel S and Charpentier E. (2018). The Biology of CRISPR-Cas: Backward and Forward. Cell, 172(6), 1239–1259.

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Charpentier E. (2018). Spotlight on… Emmanuelle Charpentier. FEMS Microbiology Letters, 365(4).

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Labuhn M, Adams FF, Ng M, Knoess S, Schambach A, Charpentier EM, Schwarzer A, Mateo JL, Klusmann J-H and Heckl D. (2018). Refined sgRNA efficacy prediction improves large- and small-scale CRISPR -Cas9 applications. Nucleic Acids Research (London), 46(3), 1375–1385.

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Broglia L, Materne S, Lécrivain A-L, Hahnke K, Le Rhun A and Charpentier E. (2018). RNase Y-mediated regulation of the streptococcal pyrogenic exotoxin B. RNA Biology, 15(10), 1336–1347.

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Book Chapter (3)

2023

Alagesan K and Charpentier E. (2023). Systems-Wide Site-Specific Analysis of Glycoproteins. In K. Gevaert (Ed.), Mass Spectrometry-Based Proteomics, 151–165. New York, NY: Springer US.

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2021

Lisacek F, Alagesan K, Hayes C, Lippold S and de Haan N. (2021). Bioinformatics in Immunoglobulin Glycosylation Analysis. In Antibody Glycosylation.

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2020

Alagesan K, Hoffmann M, Rapp E and Kolarich D. (2020). Glycoproteomics Technologies in Glycobiotechnology. In Advances in Glycobiotechnology.

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Opinion (1)

2019

Davies K and Charpentier E. (2019). Finding Her Niche: An Interview with Emmanuelle Charpentier. The CRISPR Journal, 2(1), 17–22.

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Commentary (3)

2022

Zhan X and Jungblut PR. (2022). Commentary: The comparison between 2DE-MS and bottom-up LC-MS demands high-end techniques for both technologies. Electrophoresis, 43 (11), 1242-1245.

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2021

Dougan DA, Alver R and Turgay K. (2021). Exploring a potential Achilles heel of Mycobacterium tuberculosis: defining the ClpC1 interactome. The FEBS Journal, 288 (1), 95-98.

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2019

Lander ES, Baylis F, Zhang F, Charpentier E, Berg P, Bourgain C, Friedrich B, Joung JK, Li J, Liu D, Naldini L, Nie J-B, Qiu R, Schoene-Seifert B, Shao F, Terry S, Wei W and Winnacker E-L. (2019). Adopt a moratorium on heritable genome editing. Nature, 567, 165-168.

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Editorial (1)

2019

Charpentier E, Elsholz A and Marchfelder A. (2019). CRISPR-Cas: more than ten years and still full of mysteries. RNA Biology, 16(4), 377–379. Landes Bioscience.

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