Publications

Papers

Pausch, P., Abdelshahid, M., Steinchen, W., Schäfer, H., Gratani, F.L., Freibert, S.-A., Wolz, C., Turgay, K., Wilson, D.N. & Bange, G. (2020) Structural basis for regulation of the opposing (p)ppGpp synthetase and hydrolase within the stringent response orchestrator Rel. Cell Rep 32:108157. doi: 10.1016/j.celrep.2020.108157

Schäfer, H., Beckert, B., Frese, C.K., Steinchen, W., Nuss, A., Beckstette, M., Hantke, I., Driller, K., Sudzinová, P., Krásný, L., Kaever, V., Dersch, P., Bange, G., Wilson, D.N. & Turgay, K. (2020) The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis. PLoS Genet 16: e1008275. doi:10.1371/journal.pgen.1008275

Mulvenna, N., Hantke, I., Burchell, L, Nicod, S., Bell, D., Turgay, K. & Wigneshweraraj, S. (2019) Xenogeneic modulation of the ClpCP protease of Bacillus subtilis by a phage-encoded adaptor-like protein. J. Biol. Chem. 294:17501-17511 doi: 10.1074/jbc.RA119.010007

Schäfer, H., Heinz, A., Sudzinová, P., Voß, M., Hantke, I., Krásný, L. & Turgay, K. (2019) Spx, the central regulator of the heat- and oxidative stress response in B. subtilis, can repress transcription of translation-related genes. Mol. Microbiol. 111:514-33 doi: 10.1111/ mmi.14171

Hantke, I., Schäfer, H., Janczikowski, A., & Turgay, K. (2019) YocM a small heat shock protein can protect Bacillus subtilis cells during salt stress. Mol. Microbiol. 111:423-40 doi: 10.1111/mmi.14164

Diehl, A., Roske, Y., Ball, L., Chowdhury, A., Hiller, M., Molière, N., Kramer, R., Stöppler, D., Worth, C. L., Schlegel, B., Leidert, M., Cremer, N., Erdmann, N., Lopez, D., Stephanowitz, H., Krause, E., van Rossum, B.-J., Schmieder, P., Heinemann, U., Turgay, K., Akbey, Ü. & Oschkinat, H. (2018) Structural changes of TasA in biofilm formation of Bacillus subtilis. Proc. Natl. Acad. Sci. USA 115:3237-42 doi:10.1073/pnas.1718102115

Carroni, M., Franke, K.B., Maurer, M., Jäger, J., Hantke, I., Gloge, F., Linder, D., Gremer, S., Turgay, K., Bukau, B. & Mogk, A. (2017) Regulatory coiled-coil domains promote head-to-head assemblies of AAA+chaperones essential for tunable activity control. eLife 6:e30120 doi: 10.7554/eLife.30120

Beckert, B., Abdelshahid, M., Schäfer, H., Steinchen, W., Arenz, S., Berninghausen, O., Beckmann, R., Bange, G., Turgay, K. & Wilson, D.N. (2017) Structure of the Bacillus subtilis hibernating 100S ribosome reveals the basis for 70S dimerization. EMBO J. 36:2061-72 doi: 10.15252/embj.201696189

Molière, N., Hoßmann, J., Schäfer, H. & Turgay, K. (2016) Role of Hsp100/Clp protease complexes in controlling the regulation of motility in Bacillus subtilis. Front. Microbiol. 7:315. doi: 10.3389/fmicb.2016.00315

Runde, S., Molière, N., Heinz, A., Maisonneuve, E., Janczikowski, A., Elsholz, A.K.W., Gerth, U., Hecker, M. & Turgay, K. (2014) The role of thiol oxidative stress response in heat-induced protein aggregate formation during thermotolerance in Bacillus subtilis. Mol. Microbiol. 91:1036-52. doi: 10.1111/mmi.12521

Elsholz, A., Turgay, K., Michalik, S., Hessling, B., Gronau, K., Oertel, D., Mäder, U., Bernhardt, J., Becher, D., Hecker, M. & Gerth, U. (2012) Global impact of protein arginine phosphorylation on the physiology of Bacillus subtilis. Proc. Natl. Acad. Sci. USA 109: 7451–56. doi: 10.1073/pnas.1117483109

Fuhrmann, J., Schmidt, A., Spiess, S., Lehner, A., Turgay, K., Mechtler, K., Charpentier, E. & Clausen, T. (2009) McsB Is a Protein Arginine Kinase That Phosphorylates and Inhibits the Heat-Shock Regulator CtsR. Science 324:1323-27. doi: 10.1126/science.1170088

Kirstein, J., Hoffmann, A., Lilie, H., Schmidt, R., Rübsamen-Waigmann, H., Brötz-Oesterhelt, H., Mogk, A. & Turgay, K. (2009) The antibiotic ADEP reprograms ClpP, switching it from a regulated to an uncontrolled protease. EMBO Mol. Med. 1:37-49. doi: 10.1002/emmm.200900002

Kirstein, J., Strahl, H., Moliere, N., Hamoen, L.W. & Turgay K. (2008) Localization of general and regulatory proteolysis in Bacillus subtilis cells. Mol. Microbiol. 70:682-694. doi: 10.1111/j.1365-2958.2008.06438.x

Haslberger, T., Zdanowicz, A., Brand, I., Kirstein, J., Turgay, K., Mogk, A. & Bukau, B. (2008) Protein disaggregation by the AAA+ chaperone ClpB involves partial threading of looped polypeptide segments. Nat. Struct. Mol. Biol. 15:641-50. doi: 10.1038/nsmb.1425

Erbse, A.H., Wagner, J.N., Truscott, K.N., Spall, S.K., Kirstein, J., Zeth, K., Turgay, K., Mogk, A., Bukau, B. & Dougan, D.A. (2008) Conserved residues in the N-domain of the AAA+ chaperone ClpA regulate substrate recognition and unfolding. FEBS J. 275:1400-10. doi: 10.1111/j.1742-4658.2008.06304.x

Kirstein, J., Dougan, D.A., Gerth, U., Hecker, M. & Turgay, K. (2007) The tyrosine kinase McsB is a regulated adaptor protein for ClpCP. EMBO J. 26:2061-70. doi: 10.1038/sj.emboj.7601655

Kirstein, J., Schlothauer, T., Dougan, D.A., Lilie, H., Tischendorf, G., Mogk, A., Bukau, B. & Turgay, K. (2006) Adaptor protein controlled oligomerization activates the AAA+ protein ClpC. EMBO J. 25:1481-91. doi: 10.1038/sj.emboj.7601042

Andersson, F.I., Blakytny, R., Kirstein, J., Turgay, K., Bukau, B., Mogk, A. & Clarke, A.K. (2006) Cyanobacterial ClpC/Hsp100 protein displays intrinsic chaperone activity. J. Biol. Chem. 281:5468-75. doi: 10.1074/jbc.M509661200

Kirstein, J., Zühlke, D., Gerth, U., Turgay, K. & Hecker, M. (2005) A tyrosine kinase and its activator control the activity of the CtsR heat shock repressor in B. subtilis. EMBO J. 24:3435-45. doi: 10.1038/sj.emboj.7600780

Schlothauer, T., Mogk, A., Dougan, D.A., Bukau, B. & Turgay, K. (2003) MecA, an adaptor protein necessary for ClpC chaperone activity. Proc. Natl. Acad. Sci. USA 100:2306-11. doi:

Turgay, K., Persuh, M., Hahn, J. & Dubnau, D. (2001) Roles of the two ClpC ATP binding sites in the regulation of competence and the stress response. Mol. Microbiol. 42: 717-727. doi: 10.1046/j.1365-2958.2001.02623.x

Persuh, M., Turgay, K., Mandic-Mulec, I. & Dubnau, D. (1999) The N- and the C-terminal domains of MecA recognize different partners in the competence molecular switch. Mol. Microbiol. 33: 886-94. doi: 10.1046/j.1365-2958.1999.01544.x

Turgay, K., Hahn, J., Burghoorn, J. & Dubnau, D. (1998) Competence in Bacillus subtilis is controlled by regulated proteolysis of a transcription factor. EMBO J. 17: 6730-38. doi: 10.1093/emboj/17.22.6730

Chong, P.P., Podmore, S.M., Kieser, H.M., Redenbach, M., Turgay, K., Marahiel, M.A., Hopwood, D.A. & Smith, C.P. (1998) Physical identification of a chromosomal locus encoding biosynthetic genes for the lipopeptide calcium-dependent antibiotic (CDA) of Streptomyces coelicor A3(2). Microbiology 144: 193-199. doi: 10.1099/00221287-144-1-193

Turgay, K., Hamoen, L.W., Venema, G. & Dubnau, D. (1997) Biochemical characterization of a molecular switch involving the heat shock protein ClpC, which controls the activity of ComK, the competence transcription factor of Bacillus subtilis. Genes & Dev. 11: 119-128. doi: 10.1101/gad.11.1.119

Turgay, K. & Marahiel, M.A. (1995) The gtcRS operon coding for two-component system regulatory proteins is located adjacent to the grs operon of Bacillus brevis. DNA Sequence 5: 283-290. doi: 10.3109/10425179509030982

Turgay, K. & Marahiel, M.A. (1994) A general approach for identifying and cloning of peptide synthetase genes. Peptide Res. 7: 238-241.

Turgay, K., Krause, M. & Marahiel, M.A. (1992) Four homologous domains in the primary structure of GrsB are related to domains in a superfamily of adenylate forming enzymes. Mol. Microbiol. 6: 529-546. doi: 10.1111/j.1365-2958.1992.tb01451.x

Kohne, B., Marquardt, P., Praefcke, K., Psaras, P., Stephan, W. & Turgay, K. (1986) Monothioscyllitol ethers as discogens and double discogens. Chimia 40: 360-2.

Commentaries/Previews

Dougan, D.A., Alver, R. & Turgay, K. (2021) Exploring a potential Achilles heel of Mycobacterium tuberculosis: defining the ClpC1 interactome. FEBS J. 288:95-99. doi: 10.1111/febs.15430

Dougan, D.A., Hantke, I. & Turgay, K. (2018) Dysregulating ClpP: From Antibiotics to Anticancer? Cell Chem. Biol. 25:929-30. doi: 10.1016/j.chembiol.2018.08.002

Molière, N. & Turgay, K. (2014) The key to unlock the Hsp100/Clp protein degradation machines of Mycobacterium. Mol. Microbiol. 93: 583-86. doi: 10.1111/mmi.12696

Meeting Reports

Hengge, R., Häussler, S., Pruteanu, M., Stülke, J., Tschowri, N. & Turgay K. (2019) Recent Advances and Current Trends in Nucleotide Second Messenger Signaling in Bacteria, J. Mol. Biol. 431: 908–927 doi: 10.1016/j.jmb.2019.01.014

Reviews

Hantke, I., Schäfer, H., Kramer, R. & Turgay K. (2019). Das stressige Leben des Bacillus subtilis. Biospektrum (2019) 25:150, doi: 10.1007/s12268-019-1023-0

Schäfer, H. & Turgay, K. (2019) Spx, a versatile regulator of the Bacillus subtilis stress response. Curr. Genet. 65:871-76, doi: 10.1007/s00294-019-00950-6

Elsholz AKW, Birk MS, Charpentier E, Turgay K. (2017) Functional Diversity of AAA+ Protease Complexes in Bacillus subtilis, Front. Mol. Biosci. 4:44. doi: 10.3389/fmolb.2017.00044

Mijakovic, I., Grangeasse, C. & Turgay, K. (2016) Exploring the diversity of protein modifications: special bacterial phosphorylation systems. FEMS Microbiol. Rev. 40: 398-417. doi: 10.1093/femsre/fuw003

Moliere, N. & Turgay K. (2009) Chaperone-Protease Systems in Regulation and Protein Quality Control in Bacillus subtilis. Res. Microbiol. 160: 637-644. doi: 10.1016/j.resmic.2009.08.020

Kirstein, J., Moliere, N., Dougan, D.A. & Turgay K. (2009) Adapting the machine: Adaptor proteins for Hsp100/Clp and AAA+ proteases. Nat. Rev. Microbiol. 7:589-99. doi: 10.1038/nrmicro2185

Kirstein, J. & Turgay K. (2005) A new Tyrosine Phosphorylation Mechanism Involved in Signal Transduction in Bacillus subtilis. J. Mol. Microbiol. Biotechnol. 9:182-188. doi: 10.1159/000089646

Mogk, A., Dougan, D.A., Weibezahn, J., Schlieker, C., Turgay, K. & B. Bukau. (2004) Broad yet high substrate specificity: the challenge of AAA+ proteins. J. Struct. Biol. 146: 90-98. doi: 10.1016/j.jsb.2003.10.009

Dougan, D.A., Mogk A., Zeth K., Turgay K. & Bukau B. (2002) AAA+ proteins and substrate recognition, it all depends on their partner in crime. FEBS Lett. 529: 6-10. doi: 10.1016/s0014-5793(02)03179-4

Editorial

Hengge, R. & Turgay K. (2009) Proteolysis in prokaryotes – from molecular machines to a systems perspective. Res. Microbiol. 160: 615-617. doi: 10.1016/j.resmic.2009.09.007

(for a special issue on proteolysis in prokaryotes: protein quality control and regulatory principles. Edited by Regine Hengge and Kürşad Turgay)

Bookchapters

Turgay, K. (2017) General and Regulatory Proteolysis in Bacillus subtilis; p 191-222 In: "Bacillus: Cellular and Molecular Biology (Third edition)”, P.L. Graumann (ed.) (Norfolk, UK: Caister Academic Press)

Moliere, N. & Turgay, K. (2013) General and Regulatory Proteolysis in Bacillus subtilis; p 73-103 In: " Regulated Proteolysis in Microorganisms“ Subcellular Biochemistry Volume 66, D.A. Dougan ed. (Springer Netherlands)

Turgay, K. (2012) General and Regulatory Proteolysis in Bacillus subtilis; p 187-214 In: "Bacillus: Cellular and Molecular Biology", P.L. Graumann ed. (Norfolk, UK: Caister Academic Press)

Turgay K. (2011) Role of Proteolysis and Chaperones in Stress Response and Regulation p 75-90 In: Bacterial Stress Responses (Second Edition), G. Storz & R. Hengge, eds. (Washington, DC: American Society for Microbiology).

Turgay K. (2010) Regulatory proteolysis and signal transduction in bacteria, p 449-462 In: Bacterial Signaling. R. Krämer and K. Jung (eds.), (Weinheim: Wiley VCH Verlag).

Turgay K. (2007) General and Regulatory Proteolysis in Bacillus subtilis; p 215-246 In: "Bacillus: Cellular and Molecular Biology", P.L. Graumann ed. (Norfolk, UK: Caister Academic Press)

Dubnau, D. & Turgay K. (2000) The regulation of competence in Bacillus subtilis and its relation to stress response, p 249-260 In: Bacterial Stress Responses, G. Storz & R. Hengge-Aronis, eds. (Washington, DC: American Society for Microbiology).

Turgay, K., Bachmann, A., Marahiel, M., & Patil, S. (1997) Cloning of a Putative Peptide Synthetase Gene Involved in the Synthesis of Phaseolotoxin. p. 248–254 In: Pseudomonas Syringae Pathovars and Related Pathogens. Rudolph, K., Burr, T.J., Mansfield, J.W., Stead, D., Vivian, A., and Kietzell, J. (eds), (Springer Netherlands).

Go to Editor View