Publications

Original research papers

S. Hüsing, M. Halte, U. van Look, A. Guse, E.J.C. Galvez, E. Charpentier, D.F. Blair, M. Erhardt, T.T. Renault. Control of membrane barrier during bacterial type-III protein secretion.
Nature Communications  (20201) vol. 12, 3999 doi:10.1038/s41467-021-24226-1

M. Santiveri, A. Roa-Eguiara, C. Kühne, N. Wadhwa, H. C. Berg, M. Erhardt, N. M. I. Taylor. Structure and function of stator units of the bacterial flagellar motor.
Cell (2020) vol. 183, 244-257.e16 doi:10.1016/j.cell.2020.08.016

H. Cazzola, L. Lemaire, S. Acket, E. Prost, L. Duma, M. Erhardt, P. Čechová, P. Trouillas, F. Mohareb, C. Rossi, Y. Rossez. The impact of plasma membrane lipid composition on flagella-mediated adhesion of enterohemorrhagic Escherichia coli.
mSphere (2020) vol 5, e00702-20 doi:10.1128/mSphere.00702-20

J. A. Horstmann, M. Lunelli, H. Cazzola, J. Heidemann, C. Kühne, P. Steffen, S. Szefs, C. Rossi, R. K. Lokareddy, C., Wang, L. Lemaire, K. T. Hughes, C. Uetrecht, H. Schlüter, G. A. Grassl, T. E.B. Stradal, Y. Rossez, M. Kolbe, M. Erhardt. Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion.
Nature Communications (2020) vol. 11, 2013 doi:10.1038/s41467-020-15738-3

S. Felgner, I. Spöring, V. Pawar, D. Kocijancic, M. Preusse, C. Falk, M. Rhode, S. Häussler, S. Weiss, M. Erhardt. The immunogenic potential of bacterial flagella for Salmonella-mediated tumor therapy.
International Journal of Cancer (2020) 10.1002/ijc.32807 doi:10.1002/ijc.32807

S. Nakamura, Y. Hanaizumi, Y.V. Morimoto, Y. Inoue, M. Erhardt, T. Minamino, K. Namba. Direct observation of speed fluctuations of flagellar motor rotation at extremely low load close to zero.
Molecular Microbiology (2019) vol. 113, 755-765 doi:10.1111/mmi.14440

I. Bernal, J. Börnicke, J. Heidemann, D. Svergun, J. A. Horstmann, M. Erhardt, A. Tuukkanen, C. Uetrecht, M. Kolbe. Molecular organization of soluble type III secretion system sorting platform complexes.
Journal of Molecular Biology (2019) vol. 431, 3787-803 doi:10.1016/j.jmb.2019.07.004

I. Spöring, V. A. Martinez, C. Hotz, J. Schwarz-Linek, K. L. Grady, J. M. Nava-Sedeno, T. Vissers, H. M. Singer, M. Rhode, C. Bourquin, H. Hatzikirou, W. C. Poon, Y. Dufour, M. Erhardt. Hook length of the bacterial flagellum is optimized for maximal stability of the flagellar bundle.
PLOS Biology (2018) vol. 16 (9) e2006989 doi:10.1371/journal.pbio.2006989

M. Dongre, B. Singh, K. M. Aung, P. Larsson, R. Miftakhova, K. Persson, F. Askarian, M. Johannessen, J. von Hofsten, J. L. Persson, M. Erhardt, S. Tuck, B. E. Uhlin, S. N. Wai. Flagella-mediated secretion of a novel Vibrio cholerae cytotoxin affecting both vertebrate and invertebrate hosts.
Communications Biology (2018) vol. 1 59 doi:10.1128/mBio.00736-17

I. Spöring, S. Felgner, M. Preusse, D. Eckweiler, M. Rhode, S. Häussler, S. Weiss, M. Erhardt. Regulation of Flagellum Biosynthesis in Response to Cell Envelope Stress in Salmonella enterica Serovar Typhimurium.
mBio (2018) vol. 9 (3) e00736-17 doi:10.1128/mBio.00736-17

E. Ward, T. T. Renault, E. A. Kim, M. Erhardt, K. T. Hughes, D. F. Blair. Type-III Secretion Pore Formed by Flagellar Protein FliP.
Molecular Microbiology (2018) vol. 107 (1) 94?103 doi:10.1111/mmi.13870

S. Felgner, D. Kocijancic, M. Frahm, U. Heise, K. Zimmermann, M. Erhardt, S. Weiss. Engineered Salmonella enterica serovar Typhimurium overcome limitations of anti-bacterial immunity in bacteria-mediated tumor therapy.
OncoImmunology (2018) vol. 7 (2) e1382791 doi:10.1080/2162402X.2017.1382791

F. D. Fabiani, T. T. Renault, B. Peters, T. Dietsche, E. J. C. Galvez, A. Guse, K. Freier, E. Charpentier, T. Strowig, M. Franz-Wachtel, B. Macek, S. Wagner, M. Hensel, M. Erhardt. A flagellum-specific chaperone facilitates assembly of the core type-III export apparatus of the bacterial flagellum.
PLOS Biology (2017) vol. 15 (8) e2002267 doi:10.1371/journal.pbio.2002267

S. Thiemann, N. Smit, T. Schauer, U. Roy, E. J.C. Gàlvez, J. Helmecke, T. Robin Lesker, M. Basic, A. Bleich, A. D. Goodmann, U. Kalinke, R. A. Flavell, M. Erhardt, T. Strowig. Enhancement of IFN-gamma production in CD4+ T cells by distinct commensals ameliorates Salmonella induced disease.
Cell Host & Microbe (2017) 10.1016/j.chom.2017.05.005 doi:10.1016/j.chom.2017.05.005

D. Kocijancic, S. Felgner, T. Schauer, M. Frahm, U. Heise, K. Zimmermann, M. Erhardt, S. Weiss. Local application of bacteria improves safety of Salmonella-mediated tumor therapy and retains advantages of systemic infection.
Oncotarget (2017) 10.18632/oncotarget.18392 doi:/10.18632/oncotarget.18392

G. Paradis, F. F. V. Chevance, W. Liou, T. T. Renault, K. T. Hughes, S. Rainville,M. Erhardt . Variability in bacterial flagella re-growth patterns after breakage.
Scientific Reports (2017) 10.1038/s41598-017-01302-5 doi:10.1038/s41598-017-01302-5

J. Horstmann, E. Zschieschang, T. Truschel, J. de Diego, M. Lunelli, M. Rohde, T. May, T. Strowig, T. Stradal, M. Kolbe, M. Erhardt. Flagellin phase-dependent swimming on epithelial cell surfaces contributes to productive Salmonella gut colonization.
Cellular Microbiology (2017) 10.1111/cmi.12739 doi:10.1111/cmi.12739

T. T. Renault, A. O. Abraham, T. Bergmiller, G. Paradis, S. Rainville, E. Charpentier, C. C. Guet, Y. Tu, K. Namba, J. P. Keener, T. Minamino, M. Erhardt. Bacterial flagella grow through an injection-diffusion mechanism.
eLife (2017) 10.7554/eLife.23136 doi:10.7554/eLife.23136

M. Erhardt, P. Wheatley, E. A. Kim, T. Hirano, Y. Zhang, M. K. Sarkar, K. T. Hughes, D. F. Blair. Mechanism of type-III protein secretion: Regulation of FlhA conformation by a functionally critical charged-residue cluster.
Molecular Microbiology (2017) 10.1111/mmi.13623 doi:10.1111/mmi.13623

S. Felgner, M. Frahm, D. Kocijancic, M. Rohde, D. Eckweiler, A. Bielecka, E. Bueno, F. Cava, W.-R. Abraham, R. Curtiss III, S. Häussler, M. Erhardt, S. Weiss. AroA deficient Salmonella Typhimurium is more than a metabolically attenuated mutant.
mBio (2016) vol. 7 (5) e01220-16 doi:10.1128/mBio.01220-16

B. Barlag, O. Beutel, D. Janning, F. Czarniak, C. P. Richter, R. Kurre, F. Fabiani, M. Erhardt, J. Piehler, M. Hensel. Single molecule super-resolution imaging of proteins in living Salmonella enterica using self-labeling enzymes.
Scientific Reports (2016) vol. 6 p.31601 doi:10.1038/srep31601

C. Kühne, H. M. Singer, E. Grabisch, L. Codutti, T. Carlomagno, A. Scrima, M. Erhardt. RflM mediates target specificity of the RcsCDB phosphorelay system for transcriptional repression of flagellar synthesis in Salmonella enterica.
Molecular Microbiology (2016) vol. 101 (5) 841-55 doi:10.1111/mmi.13427

S. Felgner, D. Kocijancic, M. Frahm, R. Curtiss III, M. Erhardt, S. Weiss. Optimizing Salmonella enterica Serovar Typhimurium for Bacteria-mediated Tumor Therapy.
Gut Microbes (2016) vol. 7 (2) 177-77 doi:10.1080/19490976.2016.1155021

J. A. Deditius, S. Felgner, I. Spöring, C. Kühne, M. Frahm, M. Rohde, S. Weiss, M. Erhardt. Characterization of novel factors involved in swimming and swarming motility in Salmonella enterica serovar Typhimurium.
PLOS ONE (2015) vol. 10 (8) e0135351 doi:10.1371/journal.pone.0135351

M. Frahm, S. Felgner, D. Kocijancic, M. Rohde, M. Hensel, R. Curtiss III, M. Erhardt, S. Weiss. Efficiency of conditionally attenuated Salmonella Typhimurium in bacteria mediated tumour therapy.
mBio (2015) vol. 6 (2) e00254-15  doi:/10.1128/mBio.00254-15

R. W. Hendrix, C.-C. Ko, D. Jacobs-Sera, G. F. Hatfull, A. M. Kropinski, J. M. Denyes, M. Erhardt, K. T. Hughes, S. R. Casjens. The genome sequence of Salmonella phage Chi.
Genome Announcements (2015) vol. 3 (1) e01229-14 doi:10.1128/genomeA.01229-14

M. Erhardt, M. E. Mertens, F. D. Fabiani, K. T. Hughes. ATPase-independent type-III protein secretion in Salmonella enterica.
PLOS Genetics (2014) vol. 10 (11) e1004800 doi:10.1371/journal.pgen.1004800

H. M. Singer, M. Erhardt, K. T. Hughes. Comparative analysis of the secretion capability of early and late flagellar type III secretion substrates.
Molecular Microbiology (2014) vol. 93, 505-20 doi:10.1111/mmi.12675

H. M. Singer, C. Kühne, J. A. Deditius, K. T. Hughes, M. Erhardt. The Salmonella Spi1 virulence regulatory protein HilD directly activates transcription of the flagellar master operon flhDC.
Journal of Bacteriology (2014) vol. 196, 1448-57 doi:10.1128/JB.01438-13

H. M. Singer, M. Erhardt, K. T. Hughes. RflM functions as a transcriptional repressor in the autogenous control of the Salmonella flagellar master operon flhDC.
Journal of Bacteriology (2013) vol. 195, 4274-82. doi:10.1128/JB.00728-13

H. M. Singer, M. Erhardt, A. M. Steiner, M.-M. Zhang, D. Yoshikami, G. Bulaj, B. M. Olivera, K. T. Hughes. Selective purification of recombinant neuroactive peptides using the flagellar type III secretion system.
mBio (2012) vol. 29 (3) e00115-12 doi:10.1128/mBio.00115-12

A. Takaya, M. Erhardt, K. Karata, K. Winterberg, T. Yamamoto, K. T. Hughes. YdiV: a dual function protein that targets FlhDC for ClpXP-dependent degradation by promoting release of DNA-bound FlhDC complex.
Molecular Microbiology (2012) vol. 83 (6) 1268-84 doi:10.1111/j.1365-2958.2012.08007.x

M. Erhardt, H. M. Singer, D. H. Wee, J. P. Keener, K. T. Hughes. An infrequent molecular ruler controls flagellar hook length in Salmonella enterica.
The EMBO Journal (2011) vol. 30 2948-61 doi:10.1038/emboj.2011.185

M. Erhardt, T. Hirano, Y. Su, K. Paul, D. H. Wee, S. Mizuno, S.-I. Aizawa, K. T. Hughes. The role of the FliK molecular ruler in hook-length control in Salmonella enterica.
Molecular Microbiology (2010) vol. 75 (5) 1272-84 doi:10.1111/j.1365-2958.2010.07050.x

M. Erhardt, K. T. Hughes. C-ring requirement in flagellar type III secretion is bypassed by FlhDC upregulation.
Molecular Microbiology (2010) vol. 75 (2) 376-93 doi:10.1111/j.1365-2958.2009.06973.x

A. Koplin, S. Preissler, Y. Ilina, M. Koch, A. Scior, M. Erhardt, E. Deuerling. A dual function for chaperones SSB-RAC and the NAC nascent polypeptide-associated complex on ribosomes.
Journal of Cell Biology (2010) vol. 189 (1) 57-68 doi:10.1083/jcb.200910074

M. Erhardt, R. D. Wegrzyn, E. Deuerling. Extra N-Terminal Residues Have a Profound Effect on the Aggregation Properties of the Potential Yeast Prion Protein Mca1.
PLOS ONE (2010) vol. 5 (3) e9929 EP doi:10.1371/journal.pone.0009929

K. Paul, M. Erhardt, T. Hirano, D. F. Blair, K. T. Hughes. Energy source of flagellar type III secretion.
Nature (2008) vol. 451 (7177) 489-92  doi:10.1038/nature06497

F. F. V. Chevance, M. Erhardt, C. Lengsfeld, S.-J. Lee, W. Boos. Mlc of Thermus thermophilus: a Glucose-Specific Regulator for a Glucose/Mannose ABC Transporter in the Absence of the Phosphotransferase System.
Journal of Bacteriology (2006) vol. 188 (18) 6561-71 doi:10.1128/JB.00715-06

Reviews

P. F. Popp, M. Erhardt. With or without you: crosstalk between cell division and flagellum assembly.
Developmental Cell (2021) vol. 56 10.1016/j.devcel.2021.02.013 doi:10.1016/j.devcel.2021.02.013

M. Halte, M. Erhardt. Protein Export via the Type III Secretion System of the Bacterial Flagellum.
Biomolecules (2021) vol. 11 (2), 186 doi:10.3390/biom11020186

C. Kühne, A. Guse, S. Hüsing, M. Erhardt. Bacterial Flagella.
eLS. John Wiley & Sons Ltd, Chichester (2020) 10.1002/9780470015902.a0000301.pub3 doi:10.1002/9780470015902.a0000301.pub3

T. T. Renault, A. Guse, M. Erhardt. Export Mechanisms and Energy Transduction in Type-III Secretion Machines.
Current Topics in Microbiology and Immunology (2019) doi:10.1007/82_2019_166

A. Adela Miranda-CasoLuengo, S. C. Kary, M. Erhardt, C. Kröger. Small RNA, big effect: control of flagellin production.
Trends in Microbiology (2017) S0966-842X(17)30230-5 doi:10.1016/j.tim.2017.10.003

S. Felgner, V. Pawar, D. Kocijancic, M. Erhardt, S. Weiss. Tumour-targeting bacteria-based cancer therapies for increased specificity and improved outcome.
Microbial Biotechnology (2017) vol. 10 1074-1078 doi:10.1111/1751-7915.12787

M. Erhardt. Energy requirements for protein secretion via the flagellar type-III secretion system.
Methods in Molecular Biology - Bacterial Protein Secretion Systems (2017) vol. 1615 449-457 doi:10.1007/978-1-4939-7033-9_30

M. Erhardt. Fluorescent microscopy techniques to study hook length control and flagella formation.
Methods in Molecular Biology - The Bacterial Flagellum: Methods and Protocols (2017) vol. 1593 37-46 doi:10.1007/978-1-4939-6927-2_3

M. Erhardt. Strategies to block bacterial pathogenesis by interference with motility and chemotaxis.
Current Topics in Microbiology and Immunology (2016) vol. 398 185-205 doi:10.1007/82_2016_493

M. Erhardt and P. Dersch. Regulatory principles governing Salmonella and Yersinia virulence.
Frontiers in Microbiology Review (2015) vol. 6 no. 00949 doi:10.3389/fmicb.2015.00949

K. T. Hughes, M. Erhardt. Bacterial Flagella.
eLS. John Wiley \& Sons Ltd, Chichester (2011) 10.1002/9780470015902.a0000301.pub2  doi:10.1002/9780470015902.a0000301.pub2

M. Erhardt, K. Namba, K. T. Hughes. Bacterial Nanomachines: The Flagellum and Type III Injectisome.
Cold Spring Harbor Perspectives in Biology (2010) vol. 2 (11) a000299 doi:10.1101/cshperspect.a000299

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